Recently developed super‐resolution microscopy techniques are changing our understanding of lipid rafts and membrane organisation in general. The lipid raft hypothesis postulates that cholesterol can drive the formation of ordered domains within the plasma membrane of cells, which may serve as platforms for cell signalling and membrane trafficking. There is now a wealth of evidence for these domains. However, their study has hitherto been hampered by the resolution limit of optical microscopy, making the definition of their properties problematic and contentious. (...) New microscopy techniques circumvent the resolution limit and, for the first time, allow the fluorescence imaging of structures on length scales below 200 nm. This review describes such techniques, particularly as applied to the study of membrane organisation, synthesising newly emerging facets of lipid raft biology into a state‐of‐the art model.Editor's suggested further reading in BioEssays: Super‐resolution imaging prompts re‐thinking of cell biology mechanisms Abstract and Quantitative analysis of photoactivated localization microscopy (PALM) datasets using pair‐correlation analysis Abstract. (shrink)

In _Did God Care?_ Dylan Burns offers the first comprehensive survey of providence (_pronoia_) in ancient philosophy, from Plato to Plotinus, that takes into full account the importance and innovations of early Christian thinkers, including Coptic Gnostic and Syriac sources.

Walter Savage Landor's exasperated marginal comment on line 13 of Horace, C. 1. 4 has sent modern commentators scurrying to the poem's defence. The skirmish has been won for Horace, but at the expense perhaps of magnifying the importance of line 13: A. Y. Campbell insisted that pallida mors, far from being irrelevant, was ‘the focus of the whole poem’.

Largely due to the cultural and political shift of the Enlightenment, Western societies in the eighteenth century emerged from sectarian conflict and embraced a more religiously moderate path. In nine original essays, leading scholars ask whether exporting the Enlightenment solution is possible—or even desirable—today. Contributors begin by revisiting the Enlightenment's restructuring of the West, examining its ongoing encounters with Protestant and Catholic Christianity, Judaism, Islam, and Hinduism. While acknowledging the necessity of the Enlightenment emphasis on toleration and peaceful religious coexistence, (...) these scholars nevertheless have grave misgivings about the Enlightenment's spiritually thin secularism. The authors ultimately upend both the claim that the West's experience offers a ready-made template for the world to follow and the belief that the West's achievements are to be ignored, despised, or discarded. (shrink)

George Yancy gathers white scholarship that dwells on the experience of whiteness as a problem without sidestepping the question’s implications for Black people or people of color. This unprecedented reversion of the “Black problem” narrative challenges contemporary rhetoric of a color-evasive world in a critically engaging and persuasive study.

Recent EEG studies on the early postmortem interval that suggest the persistence of electrophysiological coherence and connectivity in the brain of animals and humans reinforce the need for further investigation of the relationship between the brain’s activity and the dying process. Neuroscience is now in a position to empirically evaluate the extended process of dying and, more specifically, to investigate the possibility of brain activity following the cessation of cardiac and respiratory function. Under the direction of the Center for Healthy (...) Minds at the University of Wisconsin-Madison, research was conducted in India on a postmortem meditative state cultivated by some Tibetan Buddhist practitioners in which decomposition is putatively delayed. For all healthy baseline and postmortem subjects presented here, we collected resting state electroencephalographic data, mismatch negativity, and auditory brainstem response. In this study, we present HB data to demonstrate the feasibility of a sparse electrode EEG configuration to capture well-defined ERP waveforms from living subjects under very challenging field conditions. While living subjects displayed well-defined MMN and ABR responses, no recognizable EEG waveforms were discernable in any of the tukdam cases. (shrink)

Phenomenologically grounded research on pregnancy is a thriving area of activity in feminist studies and related disciplines. But what has been largely omitted in this area of research is the experience of childbirth itself. This paper proposes a phenomenological analysis of childbirth inspired by the work of Merleau-Ponty. The paper proceeds from the conviction that the concept of anonymity can play a critical role in explicating the affective structure of childbirth. This is evident in at least two respects. First, the (...) concept of anonymity gives structural specificity to the different levels of bodily existence at work in childbirth. Second, the concept of anonymity can play a powerful explanatory role in accounting for the sense of strangeness accompanying childbirth. To flesh these ideas out, I focus on two attributes of birth, sourced from first-person narratives of childbirth. The first aspect concerns the sense of leaving one’s body behind during childbirth while the second aspect concerns the sense of strangeness accompanying the first encounter with the baby upon successful delivery. I take both of these aspects of childbirth seriously, treating them as being instructive not only of the uniqueness of childbirth but also revealing something important about bodily life more generally. Accordingly, the paper unfolds in three stages. First, I will critically explore the concept of anonymity in Merleau-Ponty; second, I will apply this concept to childbirth; finally, I will provide an outline of how childbirth sheds light on the broader nature of bodily life. (shrink)

In this paper I argue for a doctrine I call ?infallibilism?, which I stipulate to mean that If S knows that p, then the epistemic probability of p for S is 1. Some fallibilists will claim that this doctrine should be rejected because it leads to scepticism. Though it's not obvious that infallibilism does lead to scepticism, I argue that we should be willing to accept it even if it does. Infallibilism should be preferred because it has greater explanatory power (...) than fallibilism. In particular, I argue that an infallibilist can easily explain why assertions of ?p, but possibly not-p? (where the ?possibly? is read as referring to epistemic possibility) is infelicitous in terms of the knowledge rule of assertion. But a fallibilist cannot. Furthermore, an infallibilist can explain the infelicity of utterances of ?p, but I don't know that p? and ?p might be true, but I'm not willing to say that for all I know, p is true?, and why when a speaker thinks p is epistemically possible for her, she will agree (if asked) that for all she knows, p is true. The simplest explanation of these facts entails infallibilism. Fallibilists have tried and failed to explain the infelicity of ?p, but I don't know that p?, but have not even attempted to explain the last two facts. I close by considering two facts that seem to pose a problem for infallibilism, and argue that they don't. (shrink)

Seven COVID-19 vaccines are now being distributed and administered around the world (figure correct at the time of submission), with more on the horizon. It is widely accepted that healthcare workers should have high priority. However, questions have been raised about what we ought to do if members of priority groups refuse vaccination. Using the case of influenza vaccination as a comparison, we know that coercive approaches to vaccination uptake effectively increase vaccination rates among healthcare workers and reduce patient morbidity (...) if properly implemented. Using the principle of least restrictive alternative, we have developed an intervention ladder for COVID-19 vaccination policies among healthcare workers. We argue that healthcare workers refusing vaccination without a medical reason should be temporarily redeployed and, if their refusal persists after the redeployment period, eventually suspended, in order to reduce the risk to their colleagues and patients. This ‘conditional’ policy is a compromise between entirely voluntary or entirely mandatory policies for healthcare workers, and is consistent with healthcare workers’ established professional, legal and ethical obligations to their patients and to society at large. (shrink)

In an era of transition and tension in American health care, Dorothy M. Owens offers a model of empathic communication that benefits both patients and physicians. Drawing from concepts in the domains of psychology and theology, she constructs a model of empathy that is ethical and reciprocal. An integrated model of empathy, she argues, recognizes the physical, psychological, spiritual, and social nature of human beings. empathy is a clinically useful, time effective communication skill that can be taught in medical education.

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 121.3 (2000) 385-407 [Access article in PDF] Plautus' Stichus and the Political Crisis of 200 B.C. William M. Owens What to make of Stichus? Scholars have written appreciatively of its separate parts: the sisters who are loyal wives to their absent husbands, the sympathetic depiction of the parasite Gelasimus, and even the wild celebration of the slaves that ends the play. 1 However, when considering (...) Stichus as an artistic whole, scholarship has tended to blanket the play with anathema. Thus Norwood: "What of Stichus, which falls into three mere lumps?" 2 Duckworth is more discursive but no less disparaging: "The Stichus is hardly a drama; there is no real plot and complication and denouement of the usual sort are lacking. The scenes fall into three groups: these might be called 'The Abandoned Wives' (1-401), 'The Homecoming, or the Disappointed Parasite' (402-640), and 'The Carousal of the Slaves' (641-775)." 3Previous readings have focused on the relation of Stichus to Plautus' model, Menander's first Adelphoe, attributing the deficiencies in the Roman play to Plautine departures from the model, either through free invention of scenes and characters or through contaminatio, the introduction of scenes from Greek plays other than Adelphoe. 4 However, even those who believe that Plautus was more or less faithfully following the contents of Menander's Adelphoe consider Stichus to be a poorly constructed work. 5Given this general critical disparagement and the almost complete [End Page 385] loss of its model, source criticism of Stichus has come to resemble a kind of philological shadowboxing against an invisible and superior opponent. The present reading seeks to understand the difficulties of this play in terms of its Roman audience of 200 B.C. The broad outlines of this approach were developed by Segal in Roman Laughter (1987), who argued that Plautine humor was accommodated to Roman concerns and preoccupations. Wagenvoort (1931) anticipated Segal's approach with specific reference to Stichus in his suggestion that the play reflects the jubilant mood of the people who had defeated Hannibal in the previous year and recently celebrated Scipio's triumph. Such a people, he argued, were in no mood for a play constructed by the book, but wanted one that was accommodated to their mood: Plautus Stichum [composuit]... cum etiam atque etiam aliae aliunde copiae domum reverterentur, isdem fortasse diebus, quibus summo cum gaudio Romani Scipionem aspicerent triumphantem. Tali tempore non id profecto cives a poeta suo poposcerunt, ut comoediam sibi praeberet rigidis normis adstrictam quodque ad compositionem attinet omnibus numeris absolutam, sed ut spectaculum sibi offerret ad commune gaudium quam poterat maxime accommodatum. 6There is evidence that Stichus was matched to the mood of its audience; the Ludi Plebeii for which the play was produced in 200 B.C. were repeated three times, and the popularity of Stichus may have been one of the reasons for the multiple instaurationes. 7 However, the mood of the people of Rome in 200 B.C., a politically turbulent year, was more complex than summum et commune gaudium. Fresh upon the victory [End Page 386] over Hannibal, the Senate was preparing to fight a war in Greece against Philip V of Macedon. Since the autumn of 201 senatorial ambassadors had been sent to various Greek states to canvass support for Roman intervention; during this same period ambassadors from a number of Greek states had been in Rome to complain about Philip's aggressions. 8 In March 200 the consul P. Sulpicius Galba, having received Macedonia as his province, proposed a declaration of war against Philip to the Centuriate Assembly. But a tribune, Q. Baebius, spoke against the bill, and war was rejected by nearly every voting division (ab omnibus ferme centuriis antiquata est, Liv. 31.6.3). Livy reports that the people were exhausted from the length of the war they had just completed and that Baebius was able to exploit their discontent.In response, the Senate advised Galba to try again. The war was approved after a vigorous speech from the consul. Livy does... (shrink)

Cartesian skepticism about epistemic justification (‘skepticism’) is the view that many of our beliefs about the external world – e.g., my current belief that I have hands – aren’t justified. I examine the two most influential arguments for skepticism – the Closure Argument and the Underdetermination Argument – from an evidentialist perspective. For both arguments it is clear which premise the anti-skeptic must deny. The Closure Argument, I argue, is the better argument in that its key premise is weaker than (...) the Underdetermination Argument’s key premise. However, it’s also likely that the motivation for accepting both key premises is exactly the same. So there may be a sense in which both arguments provide exactly the same motivation for skepticism. Then I argue that if I I’m right about what the motivation for accepting the arguments’ key premises is, then neither argument succeeds in providing a good reason to accept skepticism. I conclude by explaining why I think epistemologists are right to expend a lot of time and effort on refuting these arguments, even if neither argument provides any motivation for skepticism. (shrink)

Rapid growth in structural and functional brain research has led to increasing ethical discussion of what to do about incidental findings within the brains of healthy neuroimaging research participants that have potential health importance, but which are beyond the original aims of the study. This dilemma has been widely debated with respect to general neuroimaging research but has attracted little attention in the context of neuromarketing studies. In this paper, I argue that neuromarketing researchers owe participants the same ethical obligations (...) as other neuroimaging researchers. The financial resources available to neuromarketing firms and the social value of neuromarketing studies should command greater attention to the elucidation and management of incidental findings. However, this needs to be balanced against finite resources available within most public health systems. (shrink)

Among the extra-physical aspects of team sports, the ways in which players talk to each other are among the more colorful but understudied dimensions of competition. To contribute an empirical basis for examining the nature of “trash talk,” we present the results of a study of 291 varsity athletes who compete in the top division among US universities. Based on a preliminary review of trash-talk topics among student-athletes, we asked participants to indicate the frequency with which they have communicated or (...) heard others talk about opposing players’ athleticism, playing ability, physical appearance, boyfriends, girlfriends, sexual behavior, parents, and home institution during competitions. Our three main findings are: Trash-talking is most commonly about the proximately important topic of playing ability while ultimately relevant topics such as physical appearance also appear to be common; Men appear to trash-talk significantly more than women, and consistently across topics; and contact sports such as football, hockey, lacrosse, and wrestling are associated with trash talk significantly more than other sports. We also examined whether the anonymity provided by face-masked helmets in “combat sports” was associated with more trash talk than contact sports played without a helmet and found no consistent association with face masks. Our findings highlight the ways in which competitors in physical sporting contests attempt to use language—often in ways that focus on players’ kin or reproductive interests—in pursuit of victory while establishing a baseline for future research into trash-talking. (shrink)

It has been forty years since the first multi-channel cochlear implant was used in Australia. While heralded in the hearing world as one of the greatest inventions in modern medicine, not everyone reflects on this achievement with enthusiasm. For many people in the Deaf community, they see the cochlear implant as a tool that reinforces a social construct that pathologizes deafness and removes Deaf identity. In this paper, I set out the main arguments for and against cochlear implantation. While I (...) conclude that, on balance, cochlear implants improve the well-being and broaden the open futures of deaf children, this does not justify mandating implants in circumstances where parents refuse them because this may compound unintended harms when society interferes in the parent-child relationship. For this reason, I argue that parental refusal of cochlear implantation falls within Gillam’s concept of the zone of parental discretion. (shrink)

Rapid technological advances have produced a variety of novel techniques that allow a comprehensive assessment of brain function to be combined with detailed information about brain structure and connectivity. Any assessment that is based on exhibited behavior after brain injury will be prone to error for a number of reasons. These questions are explored in the context of recent studies in both healthy populations and brain injured patients that have sought to investigate covert awareness through the use of functional neuroimaging. (...) Those circumstances in which functional magnetic resonance imaging data can be used to infer awareness in the absence of a behavioral response are contrasted with those circumstances in which it cannot. This distinction is fundamental for understanding and interpreting patterns of brain activity following acute brain injury and has implications for clinical care, diagnosis, prognosis, and medicolegal decision-making after serious brain injury. (shrink)

Research Ethics, Volume 18, Issue 2, Page 151-162, April 2022. In today’s online data-driven world, people constantly shed data and deposit digital footprints. When individuals access health services, governments and health providers collect and store large volumes of health information about people that can later be retrieved, linked and analysed for research purposes. This can lead to new discoveries in medicine and healthcare. In addition, when securely stored and de-identified, the privacy risks are minimal and manageable. In many jurisdictions, ethics (...) committees routinely waive the requirement for researchers to obtain consent from data subjects before using and linking these datasets in an effort to balance respect for individuals with research efficiency. In this paper, I explore the ethical justification for using routinely collected health data for research without consent. I conclude that, not only is this morally justified but also that data subjects have a moral obligation to contribute their data to such research, which would obviate the need for ethics committees to consider consent waivers. In justifying this argument, I look to the duty of easy rescue, distributive justice and draw analogies with vaccination ethics. (shrink)